Ulcerative colitis is a chronic inflammatory bowel disease of unknown cause.
Symptoms include frequent stools, diarrhea, blood in stool, abdominal pain, fever, weight loss and anemia. Standard treatment includes anti-inflammatory, immunosuppressive and biological drugs.
A substantial percentage of patients with moderate to severe active ulcerative colitis will not respond to available therapies or will eventually develop tolerance to treatment.
Cobitolimod (Kappaproct, DIMS0150) is a potential new medication for patients with moderate to severe active ulcerative colitis.
Cobitolimod is a first in class treatment that provides a local anti-inflammatory effect which in clinical trials has shown to result in significant improvements of the major clinical symptoms.
Cobitolimod has very limited systemic absorption. This gives the drug a favorable safety profile, in sharp contrast to many approved treatments.